Tottenham have agreed a £55m fee with Real Betis for midfielder Giovani Lo Celso, Sky Sports News understands.
Lo Celso, the Argentina international, is expected to travel to London on Thursday ahead of undergoing a medical and completing the move.
Betis did not include the 23-year-old in their squad for a friendly against Las Palmas on Wednesday night.
If completed, the transfer would become Spurs’ second-biggest signing – behind Tanguy Ndombele, who cost them £63m from Lyon earlier this summer.
Spurs have also held talks with Sporting Lisbon over midfielder Bruno Fernandes.